diff --git a/OptiScaler/Config.cpp b/OptiScaler/Config.cpp
index 4eeb5973..e72f5572 100644
--- a/OptiScaler/Config.cpp
+++ b/OptiScaler/Config.cpp
@@ -1128,7 +1128,13 @@ bool Config::SaveIni()
 
     // Spoofing
     {
-        ini.SetValue("Spoofing", "Dxgi", GetBoolValue(Instance()->DxgiSpoofing.value_for_config()).c_str());
+        // Save Dxgi spoofing value only if it differs from the current GPU vendor
+        bool forceSaveDxgi = Instance()->DxgiSpoofing.has_value() &&
+                             ((State::Instance().isRunningOnNvidia && Instance()->DxgiSpoofing.value()) ||
+                              (!State::Instance().isRunningOnNvidia && !Instance()->DxgiSpoofing.value()));
+
+        ini.SetValue("Spoofing", "Dxgi",
+                     GetBoolValue(Instance()->DxgiSpoofing.value_for_config(forceSaveDxgi)).c_str());
         ini.SetValue("Spoofing", "DxgiFactoryWrapping",
                      GetBoolValue(Instance()->DxgiFactoryWrapping.value_for_config()).c_str());
         ini.SetValue("Spoofing", "DxgiBlacklist", Instance()->DxgiBlacklist.value_for_config_or("auto").c_str());