diff --git a/renderdoc/driver/vulkan/vk_layer.cpp b/renderdoc/driver/vulkan/vk_layer.cpp
index 5f03fa858..fd9e8cae4 100644
--- a/renderdoc/driver/vulkan/vk_layer.cpp
+++ b/renderdoc/driver/vulkan/vk_layer.cpp
@@ -152,6 +152,9 @@ class VulkanHook : LibraryHook
     Process::RegisterEnvironmentModification(EnvironmentModification(
         EnvMod::Set, EnvSep::NoSep, "VK_LAYER_bandicam_helper_DEBUG_1", "1"));
 
+    Process::RegisterEnvironmentModification(
+        EnvironmentModification(EnvMod::Set, EnvSep::NoSep, "DISABLE_VK_LAYER_reshade_1", "1"));
+
     // fpsmon not only has a buggy layer but it also picks an absurdly generic disable environment
     // variable :(. Hopefully no other program picks this, or if it does then it's probably not a
     // bad thing to disable too
diff --git a/renderdoc/driver/vulkan/vk_replay.cpp b/renderdoc/driver/vulkan/vk_replay.cpp
index 9a2232676..7ab9424d4 100644
--- a/renderdoc/driver/vulkan/vk_replay.cpp
+++ b/renderdoc/driver/vulkan/vk_replay.cpp
@@ -5271,6 +5271,9 @@ RDResult Vulkan_CreateReplayDevice(RDCFile *rdc, const ReplayOptions &opts, IRep
   Process::RegisterEnvironmentModification(
       EnvironmentModification(EnvMod::Set, EnvSep::NoSep, "VK_LAYER_bandicam_helper_DEBUG_1", "1"));
 
+  Process::RegisterEnvironmentModification(
+      EnvironmentModification(EnvMod::Set, EnvSep::NoSep, "DISABLE_VK_LAYER_reshade_1", "1"));
+
   // fpsmon not only has a buggy layer but it also picks an absurdly generic disable environment
   // variable :(. Hopefully no other program picks this, or if it does then it's probably not a
   // bad thing to disable too